Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis.

@article{James2003MechanismsOD,
  title={Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis.},
  author={S. Jill James and Igor P Pogribny and Marta Pogribna and Barbara J Miller and Stefanie Jernigan and Stepan Melnyk},
  journal={The Journal of nutrition},
  year={2003},
  volume={133 11 Suppl 1},
  pages={3740S-3747S}
}
Using the folate/methyl-deficient rat model of hepatocarcinogenesis, we obtained evidence that may provide new insights into a major unresolved paradox in DNA methylation and cancer research: the mechanistic basis for genome-wide hypomethylation despite an increase in DNA methyltransferase activity and gene-specific regional hypermethylation. Previous studies revealed that the methyltransferase binds with higher affinity to DNA strand breaks, gaps, abasic sites, and uracil than it does to its… CONTINUE READING