Mechanisms of Control of the Free Ca2+ Concentration in the Endoplasmic Reticulum of Mouse Pancreatic β-Cells

@inproceedings{Ravier2011MechanismsOC,
  title={Mechanisms of Control of the Free Ca2+ Concentration in the Endoplasmic Reticulum of Mouse Pancreatic β-Cells},
  author={Magalie A. Ravier and Doroth{\'e}e Daro and Let{\'i}cia Prates Roma and Jean-Christophe Jonas and Rui Cheng-Xue and Frans Schuit and Patrick Gilon},
  booktitle={Diabetes},
  year={2011}
}
OBJECTIVE Sarco-endoplasmic reticulum Ca(2+)-ATPase 2b (SERCA2b) and SERCA3 pump Ca(2+) in the endoplasmic reticulum (ER) of pancreatic β-cells. We studied their role in the control of the free ER Ca(2+) concentration ([Ca(2+)](ER)) and the role of SERCA3 in the control of insulin secretion and ER stress. RESEARCH DESIGN AND METHODS β-Cell [Ca(2+)](ER) of SERCA3(+/+) and SERCA3(-/-) mice was monitored with an adenovirus encoding the low Ca(2+)-affinity sensor D4 addressed to the ER (D4ER… CONTINUE READING
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