Mechanisms of Collagen Network Organization in Response to Tissue/Organ Damage

  title={Mechanisms of Collagen Network Organization in Response to Tissue/Organ Damage},
  author={Takaoki Saneyasu and Saeko Yoshioka and Takao Sakai},
Fibrosis is a part of the wound-healing response to tissue damage and characterized by excessive accumulation of mainly type I collagen-containing extracellular matrices (ECMs). Transforming growth factor beta (TGF-β) is a profibrogenic master cytokine responsible for promoting differentiation of tissue-resident fibroblasts into myofibro‐ blasts, upregulation of ECM production, and downregulation of ECM degradation. The formation of ECM is an essential response in wound healing. Fibronectin is… 
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  • Biology, Medicine
    Liver international : official journal of the International Association for the Study of the Liver
  • 2008
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