Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection

  title={Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection},
  author={Sandeep Sheth and Debashree Mukherjea and Leonard P Rybak and Vickram Ramkumar},
  booktitle={Front. Cell. Neurosci.},
Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic agent in cancer patients has stimulated research into the causes and treatment of this side effect. It has generally been accepted that hearing loss is produced by excessive generation of reactive oxygen species (ROS) in cell of the cochlea, which led to the development of various antioxidants as otoprotective agents. Later studies show that ROS could stimulate cochlear inflammation, suggesting… CONTINUE READING

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