Mechanisms of Channel Arrest and Spike Arrest Underlying Metabolic Depression and the Remarkable Anoxia-tolerance of the Freshwater Western Painted Turtle (Chrysemys picta bellii)

@inproceedings{Pamenter2009MechanismsOC,
  title={Mechanisms of Channel Arrest and Spike Arrest Underlying Metabolic Depression and the Remarkable Anoxia-tolerance of the Freshwater Western Painted Turtle (Chrysemys picta bellii)},
  author={Matthew E Pamenter},
  year={2009}
}
NMDAR activity is related to the activity of another glutamate receptor, the α-amino-3-hydroxy5-methylisoxazole-4-propionic acid receptor (AMPAR). AMPAR blockade is neuroprotective against anoxic insult in mammals but the role of AMPARs in the turtle’s anoxia-tolerance has not been investigated. To determine if AMPAR activity changes during hypoxia or anoxia in the turtle cortex, whole-cell AMPAR currents, AMPAR-mediated excitatory postsynaptic potentials (EPSPs) and excitatory postsynaptic… CONTINUE READING

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