Mechanisms of CNS response to systemic immune challenge: the febrile response.

  title={Mechanisms of CNS response to systemic immune challenge: the febrile response.},
  author={Joel K Elmquist and Thomas E Scammell and Clifford B. Saper},
  journal={Trends in neurosciences},
  volume={20 12},
The acute-phase reaction is the multisystem response to acute inflammation. The central nervous system (CNS) mediates a coordinated set of autonomic, endocrine and behavioral responses that constitute the cerebral component of the acute-phase reaction. However, the mechanisms of immune signaling of the CNS remain controversial. Emerging evidence indicates that different parts of the acute-phase reaction are initiated by distinct mechanisms and in different brain regions. Cytokines produced as a… CONTINUE READING

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