Mechanisms of Brain Aging Regulation by Insulin: Implications for Neurodegeneration in Late-Onset Alzheimer's Disease

@inproceedings{Schuh2011MechanismsOB,
  title={Mechanisms of Brain Aging Regulation by Insulin: Implications for Neurodegeneration in Late-Onset Alzheimer's Disease},
  author={Artur Francisco Schumacher Schuh and Carlos R M Rieder and Liara Rizzi and Marcia L. F. Chaves and Matheus Roriz-Cruz},
  booktitle={ISRN neurology},
  year={2011}
}
Insulin and IGF seem to be important players in modulating brain aging. Neurons share more similarities with islet cells than any other human cell type. Insulin and insulin receptors are diffusely found in the brain, especially so in the hippocampus. Caloric restriction decreases insulin resistance, and it is the only proven mechanism to expand lifespan. Conversely, insulin resistance increases with age, obesity, and sedentarism, all of which have been shown to be risk factors for late-onset… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 109 references

Glycogen synthase kinase 3 beta induces caspase-cleaved tau aggregation in situ.

The Journal of biological chemistry • 2004
View 8 Excerpts
Highly Influenced

(Pre)diabetes, brain aging, and cognition.

Biochimica et biophysica acta • 2009
View 1 Excerpt

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