Mechanisms of B-cell synapse formation predicted by Monte Carlo simulation.

@article{Tsourkas2007MechanismsOB,
  title={Mechanisms of B-cell synapse formation predicted by Monte Carlo simulation.},
  author={Philippos K. Tsourkas and Nicole Baumgarth and Scott I Simon and Subhadip Raychaudhuri},
  journal={Biophysical journal},
  year={2007},
  volume={92 12},
  pages={4196-208}
}
The clustering of B-cell receptor (BCR) molecules and the formation of the protein segregation structure known as the "immunological synapse" at the contact region between B cells and antigen presenting cells appears to precede antigen (Ag) uptake by B cells. The mature B-cell synapse is characterized by a central cluster of BCR/Ag molecular complexes surrounded by a ring of LFA-1/ICAM-1 complexes. In this study, we investigate the biophysical mechanisms that drive immunological synapse… CONTINUE READING
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