Mechanisms of B-cell lymphoma pathogenesis

  title={Mechanisms of B-cell lymphoma pathogenesis},
  author={Ralf K{\"u}ppers},
  journal={Nature Reviews Cancer},
Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of B-cell malignancies. Most B-cell lymphomas depend on the expression of a B-cell receptor (BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells through BCR signalling seems to be an important factor for lymphoma pathogenesis. Recent insights into the lymphomagenic role of… CONTINUE READING
Highly Influential
This paper has highly influenced 36 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS