Mechanisms of Autoantibody Production in Systemic Lupus Erythematosus

  title={Mechanisms of Autoantibody Production in Systemic Lupus Erythematosus},
  author={Shuhong Han and Haoyang Zhuang and Stepan P Shumyak and Li-jun Yang and Westley H. Reeves},
  booktitle={Front. Immunol.},
Autoantibodies against a panoply of self-antigens are seen in systemic lupus erythematosus, but only a few (anti-Sm/RNP, anti-Ro/La, anti-dsDNA) are common. The common lupus autoantigens are nucleic acid complexes and levels of autoantibodies can be extraordinarily high. We explore why that is the case. Lupus is associated with impaired central or peripheral B-cell tolerance and increased circulating autoreactive B cells. However, terminal differentiation is necessary for autoantibody… CONTINUE READING
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