Mechanisms of Antimicrobial Peptide Action and Resistance

  title={Mechanisms of Antimicrobial Peptide Action and Resistance},
  author={Michael R. Yeaman and Nannette Y Yount},
  journal={Pharmacological Reviews},
  pages={27 - 55}
Antimicrobial peptides have been isolated and characterized from tissues and organisms representing virtually every kingdom and phylum, ranging from prokaryotes to humans. Yet, recurrent structural and functional themes in mechanisms of action and resistance are observed among peptides of widely diverse source and composition. Biochemical distinctions among the peptides themselves, target versus host cells, and the microenvironments in which these counterparts convene, likely provide for… 

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