Mechanisms of Antiaddictive Actions of Ibogaine a

@article{Glick1998MechanismsOA,
  title={Mechanisms of Antiaddictive Actions of Ibogaine a},
  author={Stanley D. Glick and Isabelle M. Maisonneuve},
  journal={Annals of the New York Academy of Sciences},
  year={1998},
  volume={844}
}
ABSTRACT: Ibogaine, an alkaloid extracted from Tabemanthe iboga, is being studied as a potential long‐acting treatment for oploid and stimulant abuse as well as for alcoholism and smoking. Studies in this laboratory have used animal models to characterize ibogaine's interactions with drugs of abuse, and to investigate the mechanisms responsible. Ibogaine, as well as its metabolite, noribogaine, can decrease both morphine and cocaine self‐administration for several days in some rats; shorter… Expand
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Comparative neuropharmacology of ibogaine and its O-desmethyl metabolite, noribogaine.
TLDR
Ibogaine and noribogaine are equipotent in their ability to evoke a transient stimulation of dopamine metabolism that is characterized by profound depletion of tissue DA in mesolimbic, mesocortical, and mesostriatal terminal projection areas. Expand
Ibogaine and Noribogaine: Comparing Parent Compound to Metabolite
Ibogaine is one of the psychoactive alkaloids found in the West African shrub Tabernanthe iboga. Since the 1980s, a series of US patents have claimed efficacy for ibogaine in the treatment of drug… Expand
Application of Electrophysiological Method to Study Interactions between Ibogaine and Cocaine
TLDR
The alterations in ECoG and neurotransmitter levels suggest a decreased response to COC following IBO pretreatment, seen concomitantly with increased or decreased motor activity after subsequent amphetamine or cocaine administration. Expand
Mechanisms of action of ibogaine: relevance to putative therapeutic effects and development of a safer iboga alkaloid congener.
TLDR
In this study, animal models have been used to study ibogaine's interactions with drugs of abuse, to investigate its mechanisms of action, and to help develop an iboga derivative that will have an improved safety profile. Expand
Iboga interactions with psychomotor stimulants: panacea in the paradox?
TLDR
A positive relationship exists between the effects of iboga pretreatment on stimulant-induced dopamine sensitization and stimulant self-administration behavior, and data indicate that iboga agents might attenuate stimulantSelf-Administration by reversing the neuroadaptations theoretically implicated in drug craving and compulsive drug-seeking behavior. Expand
Noribogaine (12‐Hydroxyibogamine): A Biologically Active Metabolite of the Antiaddictive Drug Ibogaine
TLDR
The present data demonstrate that NORIBO is biologically active and undoubtedly contributes to the in vivo pharmacological profile of IBO in rats, and appears less likely to produce the adverse effects associated with IBO (i.e., tremors and stress‐axis activation), suggesting that the metabolite may be a safer alternative for medication development. Expand
Noribogaine, but not 18‐MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self‐administration
TLDR
Whether noribogaine and/or 18‐MC, like ibogaine, increase GDNF expression, and whether their site of action to reduce alcohol consumption is the VTA is determined, which suggests that noribogsaine and 18-MC have different mechanisms and sites of action. Expand
18‐Methoxycoronaridine (18‐MC) and Ibogaine: Comparison of Antiaddictive Efficacy, Toxicity, and Mechanisms of Action
TLDR
The data suggest that 18‐MC has a narrower spectrum of actions and will have a substantially greater therapeutic index than ibogaine, and is likely to have an active metabolite. Expand
In vivo neurobiological effects of ibogaine and its O-desmethyl metabolite, 12-hydroxyibogamine (noribogaine), in rats.
TLDR
The present findings demonstrate that noribogaine is biologically active and undoubtedly contributes to the in vivo pharmacological profile of ibogaine in rats and appears less apt to produce the adverse effects associated with ibogain, indicating the metabolite may be a safer alternative for medication development. Expand
Long-Lasting Ibogaine Protection against NMDA-Induced Convulsions in Mice
TLDR
Ibogaine (80 mg/kg, ip) was effective in inhibiting convulsions induced by NMDA at 24 and 72 hours post administration, and [3H] MK-801 binding was significantly decreased at24 and 72 h post ibogaine, suggesting that this long lasting and complex pattern of modulation of NMDA receptors prompted by a single dose of Ibogaine may be associated to its antiaddictive properties. Expand
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