Mechanisms of Antiaddictive Actions of Ibogaine a

@article{Glick1998MechanismsOA,
  title={Mechanisms of Antiaddictive Actions of Ibogaine a},
  author={Stanley D. Glick and Isabelle M. Maisonneuve},
  journal={Annals of the New York Academy of Sciences},
  year={1998},
  volume={844}
}
ABSTRACT: Ibogaine, an alkaloid extracted from Tabemanthe iboga, is being studied as a potential long‐acting treatment for oploid and stimulant abuse as well as for alcoholism and smoking. Studies in this laboratory have used animal models to characterize ibogaine's interactions with drugs of abuse, and to investigate the mechanisms responsible. Ibogaine, as well as its metabolite, noribogaine, can decrease both morphine and cocaine self‐administration for several days in some rats; shorter… Expand
Comparative neuropharmacology of ibogaine and its O-desmethyl metabolite, noribogaine.
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Ibogaine is one of the psychoactive alkaloids found in the West African shrub Tabernanthe iboga. Since the 1980s, a series of US patents have claimed efficacy for ibogaine in the treatment of drugExpand
Application of Electrophysiological Method to Study Interactions between Ibogaine and Cocaine
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Noribogaine (12‐Hydroxyibogamine): A Biologically Active Metabolite of the Antiaddictive Drug Ibogaine
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Noribogaine, but not 18‐MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self‐administration
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Whether noribogaine and/or 18‐MC, like ibogaine, increase GDNF expression, and whether their site of action to reduce alcohol consumption is the VTA is determined, which suggests that noribogsaine and 18-MC have different mechanisms and sites of action. Expand
18‐Methoxycoronaridine (18‐MC) and Ibogaine: Comparison of Antiaddictive Efficacy, Toxicity, and Mechanisms of Action
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The data suggest that 18‐MC has a narrower spectrum of actions and will have a substantially greater therapeutic index than ibogaine, and is likely to have an active metabolite. Expand
In vivo neurobiological effects of ibogaine and its O-desmethyl metabolite, 12-hydroxyibogamine (noribogaine), in rats.
TLDR
The present findings demonstrate that noribogaine is biologically active and undoubtedly contributes to the in vivo pharmacological profile of ibogaine in rats and appears less apt to produce the adverse effects associated with ibogain, indicating the metabolite may be a safer alternative for medication development. Expand
Long-Lasting Ibogaine Protection against NMDA-Induced Convulsions in Mice
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Ibogaine (80 mg/kg, ip) was effective in inhibiting convulsions induced by NMDA at 24 and 72 hours post administration, and [3H] MK-801 binding was significantly decreased at24 and 72 h post ibogaine, suggesting that this long lasting and complex pattern of modulation of NMDA receptors prompted by a single dose of Ibogaine may be associated to its antiaddictive properties. Expand
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