Mechanisms of Action of Mycophenolic Acid

@article{Allison1993MechanismsOA,
  title={Mechanisms of Action of Mycophenolic Acid},
  author={A. Allison and W. J. Kowalski and C. Muller and E. Eugui},
  journal={Annals of the New York Academy of Sciences},
  year={1993},
  volume={696}
}

Topics from this paper

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References

SHOWING 1-10 OF 76 REFERENCES
The purine path to chemotherapy
  • G. Elion
  • Biology, Medicine
  • In Vitro Cellular & Developmental Biology
  • 2007
TLDR
Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia, gout and hyperuricemia, and herpesvirus infections, and for the prevention of organ transplant rejection. Expand
Effect of mycophenolic acid on Epstein-Barr virus infection of human B lymphocytes
TLDR
Results suggest that MPA might reduce transformed-cell proliferation in transplant patients and possibly decrease the risk of development of EBV-related lymphoproliferative disorders. Expand
Effects of immunosuppressive therapy on the rat aortic allograft model.
Human Type I and II IMP Dehydrogenases as Drug Targets
Maintenance immunosuppression with prednisolone and RS-61443 alone following liver transplantation
  • Transplant. Proc
  • 1993
Treatment of cyclophosphamide-induced hemor
  • 1993
Treatment of cyclophosphamide-induced hemorrhagic cystitis with intravesical carboprost tromethamine.
TLDR
It is suggested that carboprost tromethamine is a useful bedside therapy for hemorrhagic cystitis due to cyclophosphamide, and treatment appears to have minimal toxicity. Expand
...
1
2
3
4
5
...