Mechanisms of Action of Ladasten: Activation of Gene Expression for Neurotrophins and Mitogen-Activated Kinases

@article{Salimgareeva2012MechanismsOA,
  title={Mechanisms of Action of Ladasten: Activation of Gene Expression for Neurotrophins and Mitogen-Activated Kinases},
  author={M. Kh. Salimgareeva and Renat S. Yamidanov and Yu. V. Vakhitova and Sergey B. Seredenin},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2012},
  volume={152},
  pages={313-317}
}
We studied the effects of single treatment with ladasten (50 mg/kg) on the content of effector kinases of the mitogen-activated cascade (ERK1/ERK2), pERK1/ERK2 activity (Thr202/Tyr204), and expression of genes for neurotrophic factors BDND and NGF in the striatum, hypothalamus, and hippocampus of rats. 
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References

SHOWING 1-10 OF 30 REFERENCES
Clinically Relevant Doses of Fluoxetine and Reboxetine Induce Changes in the TrkB Content of Central Excitatory Synapses
TLDR
It is proposed that BDNF, whose synthesis is increased by antidepressants, and which is in part released at synaptic sites, binds to TrkB in PSDs, leading to the internalization of the BDNF-TrkB complex and, thus, to a decrease of TrkB at postsynaptic densities in the PSDs.
Mood Stabilizer Valproate Promotes ERK Pathway-Dependent Cortical Neuronal Growth and Neurogenesis
TLDR
It is found that chronic treatment of rats with valproate increased levels of activated phospho-ERK44/42 in neurons of the anterior cingulate, a region in whichValproate-induced increases in expression of an ERK pathway-regulated gene, bcl-2, demonstrate that valproates activates the ERK route and induces ERK pathways-mediated neurotrophic actions.
Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference.
TLDR
It is shown that an established CPP can be disrupted when reactivation associates both the conditioned context and drug administration, and systemic treatment preventing ERK activation during reexposure erases the previously learned behavioral response.
Differential effects of long-term treatment with typical and atypical antipsychotics on NGF and BDNF levels in rat striatum and hippocampus
cDNA macroarray analysis of gene expression changes in rat brain after a single administration of a 2-aminoadamantane derivative
TLDR
The analysis of hybridization on macroarrays has demonstrated that Ladasten alters the expression of 12 genes in the rat brain, and the changes in their activity explain the mechanisms of the anxiolytic and mood-stabilizing effects of the drug.
Elevated Levels of the Chemokine GRO-1 Correlate with Elevated Oligodendrocyte Progenitor Proliferation in theJimpy Mutant
TLDR
A novel mechanism by which proliferation of oligodendrocyte progenitor cells is regulated in the postnatal spinal cord in response to insult is suggested.
[DNA macroarray analysis of gene expression changes in rat brain after single administration of 2-aminoadamantane compound].
TLDR
Assessment of changes in mRNA expression of 588 genes in rat brain after acute treatment of 2-aminoadamantane compound--Ladasten showed that Ladasten induced genes are involved in the different signalling pathways, genes encoding the cytosceletal proteins, synaptic proteins, and metabolism enzymes.
Repeated l-DOPA treatment increases c-fos and BDNF mRNAs in the subthalamic nucleus in the 6-OHDA rat model of Parkinson's disease
Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes
Transcriptional regulation by MAP kinases
  • Roger J. Davis
  • Biology, Computer Science
    Molecular reproduction and development
  • 1995
TLDR
The MAP kinase pathway represents a significant mechanism of signal transduction by growth factor receptors from the cell surface to the nucleus that results in the regulation of gene expression.
...
...