Mechanisms of Action of Hormonal Emergency Contraceptives
@article{Leung2010MechanismsOA, title={Mechanisms of Action of Hormonal Emergency Contraceptives}, author={Vivian W. Y. Leung and Marc Levine and Judith A. Soon}, journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy}, year={2010}, volume={30} }
Hormonal emergency contraceptives have been used to prevent unwanted pregnancy for more than 3 decades. The mechanisms of action of the regimen containing a combination of estrogen and progestin, known as the Yuzpe regimen, and those of the levonorgestrel regimen continue to be controversial, especially over the possibility that these regimens might act by interfering with implantation of the fertilized ovum. We performed a search of the PubMed (1949‐July 2009) and EMBASE (1980‐July 2009…
28 Citations
[Effect of levonorgestrel in the ovulation, endometrium, and spermatozoa for emergency oral contraception].
- MedicineRevista peruana de medicina experimental y salud publica
- 2010
The main mechanism of action of the levonorgestrel, given at the doses recommended for EOC, is the inhibition or retardation of the ovulation, it doesn't affect the spermatozoa in their migration or egg-penetration capacities and no morphological or molecular alterations in the endometrium that could interfere with the implanted egg have been demonstrated.
Emergency Contraception: Review and Update
- MedicineCurrent Obstetrics and Gynecology Reports
- 2016
The most effective postcoital method of contraception is the copper intrauterine device (IUD).
Efecto del levonorgestrel como anticonceptivo oral de emergencia en la ovulación, el endometrio y los espermatozoides
- Medicine
- 2010
It is found that the main mechanism of action of the levonorgestrel, given at the doses recommended for EOC, is the inhibition or retardation of the ovulation, it doesn’t affect the spermatozoa in their migration or egg-penetration capacities, and no morphological or molecular alterations in the endometrium that could interfere with the implanted egg have been demonstrated.
Efficacy and safety of a levonorgestrel enteric-coated tablet as an over-the-counter drug for emergency contraception: a Phase IV clinical trial
- MedicineHuman reproduction
- 2011
The study found that E-LNG-ECP was effective, safe and well tolerated as an over-the-counter drug for emergency contraception in Chinese women, and an randomized controlled trial should be performed to compare standard LNG tablets with E- LNG- ECP.
Evaluation of the Mechanism of Action of Anti-fertility Treatment in Cases of Sexual Assault: Moral Certitude and Human Acts
- Biology
- 2017
Current rape treatment protocols are grossly inadequate and fail to provide moral certitude precluding embryocide, and careful assessment of the scientific corpus cannot rule out significant post fertilization MOA and cannot establish the minimum level of confidence necessary formoral certitude that it is not abortifacient.
Ulipristal acetate: a new emergency contraceptive
- Medicine, BiologyExpert review of clinical pharmacology
- 2011
Ulipristal acetate (UPA) is a newly developed emergency contraceptive currently available in the USA and Europe. It is approved as a 30 mg one-time dose taken within 120 h (5 days) of unprotected…
Conocimientos, actitudes y prácticas de profesionales en farmacia sobre la anticoncepción hormonal de emergencia (PAE) en Costa Rica = Knowledge, attitudes and practices of professionals in pharmacy on hormonal contraception emergency (ECP) in Costa Rica
- Medicine
- 2012
It is concluded that, despite the high level of knowledge, low prescription of emergency contraception is related to low awareness of the existing evidence of its mechanism of action.
Oral contraceptive pills: Risky or protective in case of Trichinella spiralis infection?
- BiologyParasite immunology
- 2017
Oestrogen‐containing pills established a favourable intestinal environment for Trichinella by enhancing Foxp+T‐reg.
Knowledge and beliefs about mechanism of action of birth control methods among European women.
- MedicineContraception
- 2012
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