Mechanisms of Action of Aminoglutethimide as Endocrine Therapy of Breast Cancer

  title={Mechanisms of Action of Aminoglutethimide as Endocrine Therapy of Breast Cancer},
  author={Dr P. E. L\onning and St. Kvinnsland},
During the last decade aminoglutethimide has been recognised as a valuable alternative in endocrine therapy for advanced breast cancer. Although some side effects do occur, most often these are initial effects which subside within a few weeks, and cessation of therapy is not usually indicated. Aminoglutethimide was originally introduced as an inhibitor of steroidogenesis in the adrenal cortex. It was soon recognised, however, that inhibition of the non-glandular aromatase, blocking the… CONTINUE READING


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