Mechanisms of Action for Treatments in Multiple Sclerosis

  title={Mechanisms of Action for Treatments in Multiple Sclerosis},
  author={Dr Michel Chofflon},
The etiology of multiple sclerosis (MS) is incompletely understood, and evidence suggests there may be more than one underlying cause in this disorder. Furthermore, this complex and heterogeneous autoimmune disease shows a high degree of clinical variability between patients. Therefore, in the absence of a single therapeutic target for MS, it is difficult to apply conventional drug design strategies in the search for new treatments. We review the potential mechanisms of action of several… CONTINUE READING


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Mechanism of action of mitoxantrone

  • EJ Fox
  • Neurology
  • 2004
Highly Influential
4 Excerpts

What do we know about the mechanism of action of disease-modifying treatments in MS

  • Hartung H-P, A Bar-Or
  • J Neurol
  • 2004
Highly Influential
4 Excerpts

Increases in soluble VCAM - 1 expression on peripheral blood T lymphocytes mediated by glatiramer therapy .

  • A Prat, K Biernacki, JP Antel, PA Calabresi, CM Pelfrey, LR Tranquill
  • correlate with a decrease in MRI lesions in…
  • 2005

and adhesion molecules in multiple sclerosis patients treated with interferon - beta 1 b

  • O Neuhaus, C Farina, A Yassouridis
  • Cytokines
  • 2005

Cardiac adverse effects associated with system

  • S Shapiro, Y Galboiz, N Lahat
  • Neuropharmacology
  • 2004

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