Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives.

@article{Robakis2011MechanismsOA,
  title={Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives.},
  author={Nikolaos K. Robakis},
  journal={Neurobiology of aging},
  year={2011},
  volume={32 3},
  pages={372-9}
}
Alzheimer's disease (AD) is the most common cause of dementia in the aged population. Most cases are sporadic although a small percent are familial (FAD) linked to genetic mutations. AD is caused by severe neurodegeneration in the hippocampus and neocortical regions of the brain but the cause of this neuronal loss is unclear. A widely discussed theory posits that amyloid depositions of Aβ peptides or their soluble forms are the causative agents of AD. Extensive research in the last 20 years… CONTINUE READING
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