Mechanisms of 4-quinolone resistance in quinolone-resistant and methicillin-resistant Staphylococcus aureus isolates from Japan and China.

@article{Tanaka1995MechanismsO4,
  title={Mechanisms of 4-quinolone resistance in quinolone-resistant and methicillin-resistant Staphylococcus aureus isolates from Japan and China.},
  author={Mayumi Tanaka and You Xin Zhang and Hiroyuki Ishida and Takaaki Akasaka and Kenichi Sato and Ichiro Hayakawa},
  journal={Journal of medical microbiology},
  year={1995},
  volume={42 3},
  pages={214-9}
}
Ninety-two and 33 methicillin-resistant Staphylococcus aureus (MRSA) strains were isolated in Japan and China respectively. They were categorised as ofloxacin-susceptible (MIC < 12.5 mg/L), moderately (MIC 12.5-25 mg/L) or highly (MIC > or = 50 mg/L) ofloxacin-resistant. 4-Quinolone concentrations required to inhibit purified DNA gyrase from the moderately and highly quinolone-resistant MRSA were at least 20 times higher than those required to inhibit the equivalent enzyme from quinolone… CONTINUE READING