Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db/db type 2 diabetic mice.

@article{Pereira2006MechanismsO,
  title={Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db/db type 2 diabetic mice.},
  author={Laetitia Pereira and Jan Matthes and Iris Schuster and H{\'e}ctor H. Valdivia and Stefan Herzig and Sylvain Richard and Ana M G{\'o}mez},
  journal={Diabetes},
  year={2006},
  volume={55 3},
  pages={608-15}
}
Cardiovascular disease is the leading cause of death in the diabetic population. However, molecular mechanisms underlying diabetic cardiomyopathy remain unclear. We analyzed Ca2+-induced Ca2+ release and excitation-contraction coupling in db/db obese type 2 diabetic mice and their control littermates. Echocardiography showed a systolic dysfunction in db/db mice. Two-photon microscopy identified intracellular calcium concentration ([Ca2+]i) transient decrease in cardiomyocytes within the whole… CONTINUE READING

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