Mechanisms of [ Ca 2 ] i Transient Decrease in Cardiomyopathy of db / db Type 2 Diabetic Mice

@inproceedings{Pereira2006MechanismsO,
  title={Mechanisms of [ Ca 2 ] i Transient Decrease in Cardiomyopathy of db / db Type 2 Diabetic Mice},
  author={Laetitia Pereira and Jan Matthes and Iris Schuster and H{\'e}ctor H. Valdivia and Stefan Herzig and Sylvain Richard and Ana M G{\'o}mez},
  year={2006}
}
Cardiovascular disease is the leading cause of death in the diabetic population. However, molecular mechanisms underlying diabetic cardiomyopathy remain unclear. We analyzed Ca -induced Ca release and excitation-contraction coupling in db/db obese type 2 diabetic mice and their control littermates. Echocardiography showed a systolic dysfunction in db/db mice. Two-photon microscopy identified intracellular calcium concentration ([Ca ]i) transient decrease in cardiomyocytes within the whole heart… CONTINUE READING