Mechanisms modulating skeletal muscle phenotype.

  title={Mechanisms modulating skeletal muscle phenotype.},
  author={Bert Blaauw and Stefano Schiaffino and Carlo Reggiani},
  journal={Comprehensive Physiology},
  volume={3 4},
Mammalian skeletal muscles are composed of a variety of highly specialized fibers whose selective recruitment allows muscles to fulfill their diverse functional tasks. In addition, skeletal muscle fibers can change their structural and functional properties to perform new tasks or respond to new conditions. The adaptive changes of muscle fibers can occur in response to variations in the pattern of neural stimulation, loading conditions, availability of substrates, and hormonal signals. The new… CONTINUE READING
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