Mechanisms mediating brain plasticity: IGF1 and adult hippocampal neurogenesis.

  title={Mechanisms mediating brain plasticity: IGF1 and adult hippocampal neurogenesis.},
  author={M Llorens-Mart{\'i}n and Ign{\'a}cio Torres-Aleman and Jos{\'e} Luis Trejo},
  journal={The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  volume={15 2},
This review addresses the role of serum insulin-like growth factor 1 (IGF1) as one mechanism of adult neural plasticity, specifically, its regulation of hippocampal neurogenesis among other plasticity-related processes. It is suggested that IGF has been reused advantageously both for the control of energy expenditure as a function of the organism's activity and to protect, repair, and plastically modulate the brain. Moreover, because as the main source of IGF1 in the adult organism is outside… CONTINUE READING
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