Mechanisms linking obesity to insulin resistance and type 2 diabetes

@article{Kahn2006MechanismsLO,
  title={Mechanisms linking obesity to insulin resistance and type 2 diabetes},
  author={S. Kahn and R. Hull and K. Utzschneider},
  journal={Nature},
  year={2006},
  volume={444},
  pages={840-846}
}
  • S. Kahn, R. Hull, K. Utzschneider
  • Published 2006
  • Biology, Medicine
  • Nature
  • Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in the development of insulin resistance. When insulin resistance is accompanied by dysfunction of pancreatic islet β-cells — the cells that release insulin — failure to control blood glucose levels results. Abnormalities… CONTINUE READING
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    References

    SHOWING 1-10 OF 100 REFERENCES
    Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
    • 1,684
    • PDF
    Preventing diabetes--applying pathophysiological and epidemiological evidence.
    • 37
    Type 2 Diabetes-a Matter of ß-Cell Life and Death?
    • 738
    Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
    • 5,634
    • PDF