Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice.

@article{Ferreira2005MechanismsII,
  title={Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice.},
  author={Juliano Ferreira and Karen Melina Trich{\^e}s and Rodrigo Medeiros and Jo{\~a}o Batista Calixto},
  journal={Pain},
  year={2005},
  volume={117 1-2},
  pages={171-81}
}
Protein kinase C (PKC) is able to phosphorylate several cellular components that serve as key regulatory components in signal transduction pathways of nociceptor excitation and sensitisation. Therefore, the present study attempted to assess some of the mechanisms involved in the overt nociception elicited by peripheral administration of the PKC activator, phorbol 12-myristate 13-acetate (PMA), in mice. The intraplantar (i.pl.) injection of PMA (16-1600 pmol/paw), but not its inactive analogue… CONTINUE READING