Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice

@article{Ferreira2005MechanismsII,
  title={Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice},
  author={Juliano Ferreira and Karen M. Trich{\^e}s and Rodrigo Medeiros and Jo{\~a}o B. Calixto},
  journal={Pain},
  year={2005},
  volume={117},
  pages={171-181}
}
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105 Citations
Highly Influential Citations
9
Background Citations
41
Methods Citations
16
Results Citations
3

105 Citations

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Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms

Possible participation of nitric oxide/cyclic guanosine monophosphate/protein kinase C/ATP-sensitive K(+) channels pathway in the systemic antinociception of flavokawin B.

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Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5‐HT receptors in rat primary sensory neurons

Results suggest that the PKC‐ and PKA‐mediated signalling pathways are involved in the potentiating effect of 5‐HT on TRPV1 functions through the activation of5‐HT2A and 5‐ HT7 receptors, respectively.
...

References

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It is demonstrated that PKC activation at peripheral tissues leads to the development of spontaneous nociceptive response, thermal hyperalgesia and mechanical allodynia, and in vivo evidence that peripheral PKCactivation is essential for the full establishment of the nocICEptive response induced by two different inflammatory stimuli.

A Novel Nociceptor Signaling Pathway Revealed in Protein Kinase C ε Mutant Mice

A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice.

It is shown that epinephrine-induced mechanical and thermal hyperalgesia and acetic acid-associated hyperalGESia are markedly attenuated in PKCepsilon mutant mice, but baseline nociceptor thresholds are normal, indicating that PKCEPsilon regulates nocICEptor function and suggesting thatPKCep silon inhibitors could prove useful in the treatment of pain.

Specific Involvement of PKC-ε in Sensitization of the Neuronal Response to Painful Heat

Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C.

The findings indicate that different second messenger pathways underlie acute and prolonged inflammatory pain, which may have a role in chronic inflammatory pain.

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Bradykinin‐induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord‐tail preparation in vitro

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Phosphatidylinositol 3-Kinase Activates ERK in Primary Sensory Neurons and Mediates Inflammatory Heat Hyperalgesia through TRPV1 Sensitization

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Possible contribution of protein kinase C in the effects of histamine on the visceral nociceptor activities in vitro

Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide

The absence of a current activated by PMA in most DRG neurones or in stably transfected HEK293 cells suggests that activation of PKC does not directly open VR1 channels, but instead increases the probability that they will be activated by capsaicin, heat, low pH or anandamide.
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