Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice.

@article{Lipina2010MechanismsII,
  title={Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice.},
  author={Christopher Lipina and Hannah J Kendall and Alexandra C. McPherron and Peter M. Taylor and Harinder S Hundal},
  journal={FEBS letters},
  year={2010},
  volume={584 11},
  pages={2403-8}
}
Myostatin deficiency leads to both an increased rate of protein synthesis and skeletal muscle hypertrophy. However, the mechanisms involved in mediating these effects are not yet fully understood. Here, we demonstrate that genetic loss of myostatin leads to enhanced muscle expression of both protein kinase B and mammalian target of rapamycin/S6K signalling components, consistent with their elevated activity. This is associated with a reduction in the expression of PGC1alpha and COX IV, proteins… CONTINUE READING

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