Mechanisms involved in the development of tolerance to DFP toxicity.

  title={Mechanisms involved in the development of tolerance to DFP toxicity.},
  author={Ram Chandra Gupta and Gary Patterson and Wolf D. Dettbarn},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  volume={5 6 Pt 2},
Rats treated daily with diisopropylfluorophosphate (DFP) (0.5 mg/kg, sc), an inhibitor of acetylcholinesterase (AChE) activity, exhibited the symptoms of cholinergic hyperactivity between Days 3 and 5 similar to those observed 15 min after a single acute dosage (1.5 mg/kg, sc). A significant (p less than 0.05) decrease in the activities of both AChE and cholinesterase (BuChE) (greater than 80%) occurred in muscles and in brain regions and of aliesterases in liver (greater than 92%) at this time… CONTINUE READING