Mechanisms involved in the depleting effect of cysteamine on pancreatic somatostatin.

@article{Hashimoto1987MechanismsII,
  title={Mechanisms involved in the depleting effect of cysteamine on pancreatic somatostatin.},
  author={Naotake Hashimoto and Azuma Kanatsuka and Hideichi Makino and Maya Sakurada and Shouji Yoshida},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={1987},
  volume={19 1},
  pages={11-4}
}
We investigated the effects of cysteamine on the pancreatic islet hormones and found that pancreatic somatostatin contents depleted 60 min after the oral administration of cysteamine (300 mg/kg) to rats, yet the insulin and glucagon contents remained unchanged. When pancreatic islets isolated by collagenase digestion were incubated for 60 min in Krebs-Ringer bicarbonate buffer containing 0.1, 1, or 10 mM cysteamine, cysteamine dose-dependently decreased the somatostatin content, however, only a… CONTINUE READING