Mechanisms involved in the antinociceptive and anti-inflammatory effects of bis selenide in mice.

@article{Jess2009MechanismsII,
  title={Mechanisms involved in the antinociceptive and anti-inflammatory effects of bis selenide in mice.},
  author={Cristiano Ricardo Jess{\'e} and Lucielli Savegnago and Cristina Wayne Nogueira},
  journal={The Journal of pharmacy and pharmacology},
  year={2009},
  volume={61 5},
  pages={623-30}
}
OBJECTIVES The present study examined the mechanisms involved in the antinociceptive effects of bis selenide [(Z)-2,3-bis(4-chlorophenylselanyl)prop-2-en-1-ol]. METHODS The effects of oral bis selenide were tested against licking behaviour and oedema in mice induced by formalin, serotonin, histamine, glutamate, phorbol 12-myristate 13-acetate (PMA), 8-bromoadenosine 3',5'-cyclic monophosphate (8-BrcAMP) and prostaglandin E2. The effects of a variety of receptor antagonists on the… CONTINUE READING

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