Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice

@article{Santos2003MechanismsII,
  title={Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice},
  author={Adair R. S. Santos and A. P. Trentin and J. Ferreira and R. Yunes and J. Calixto},
  journal={Brain Research},
  year={2003},
  volume={961},
  pages={269-276}
}
The pregnane compound MV8612 isolated from the rhizome of the plant Mandevilla velutina administered by intraperitoneal (i.p.), intrathecal (i.t.) or by intracerebroventricular (i.c.v.) routes caused graded and complete inhibition of the thermal hyperalgesia caused by i.t. injection of bradykinin (BK) in mice with mean ID(50) values of 7.8 micromol/kg, 33.6 and 4.6 nmol/site, respectively. Compound MV8612 (i.p.) also inhibited both the neurogenic and inflammatory pain responses to formalin with… Expand
Mechanisms involved in the antinociception caused by melatonin in mice
TLDR
Melatonin produces peripheral and central antinociception when assessed on capsaicin‐ or glutamate‐induced pain in mice through mechanisms that are likely mediated by interaction with plasma membrane‐bound melatonin receptors and modulated by opioid, serotonergic (5‐HT2A receptors), dopaminergic (D2‐receptors), adrenergic (α2−adrenoceptors) systems as well as the l‐arginine‐nitric oxide pathway. Expand
Effects of the compounds MV8608 and MV8612 obtained from Mandevilla velutina in the model of hemorrhagic cystitis induced by cyclophosphamide in rats
TLDR
The present results clearly indicate that MV8608 and MV8612 might represent important alternatives to prevent side effects, especially the nociception, following chemotherapy with CYP. Expand
Anti-edematogenic effects of velutinol A isolated from Mandevilla velutina: Evidence for a selective inhibition of kinin B1 receptor-mediated responses
TLDR
Evidence is provided that velutinol A selectively blocks the edema responses mediated by B(1) receptor activation in vivo, and this compound might represent a new non-peptidic and selective antagonist for kinin B( 1) receptors. Expand
Antinociceptive Effect of the Essential Oil Obtained from the Leaves of Croton cordiifolius Baill. (Euphorbiaceae) in Mice
TLDR
The antinociceptive effect of CcEO could be explained, at least in part, by inhibition of the glutamatergic system. Expand
Antinociceptive effect of proanthocyanidins from Croton celtidifolius bark
TLDR
Evidence is provided that 63SF exerted a pronounced systemic antinociception against chemical (acetic acid, formalin, glutamate and capsaicin tests) and thermal (hot‐plate and tail‐flick tests) nociceptive models of pain in mice at a dose that did not interfere with the locomotor activity. Expand
Diphenyl diselenide attenuates acute thermal hyperalgesia and persistent inflammatory and neuropathic pain behavior in mice
TLDR
It is indicated that diphenyl diselenide (PhSe)(2) produces systemic antiallodynic action when assessed in mechanical stimulus (VHF) in the hindpaw and also attenuates acute thermal hyperalgesia. Expand
Estudos dos mecanismos envolvidos na ação antinociceptiva causada pelo disseleneto de difenila em camundongos
TLDR
The aims of the present study were to evaluate the acute toxicity induced by diphenyl diselenide in mice using oral route of administration with the purpose of offering safety in the use of this compound and to verify the antinociceptive and antiinflammatory activities caused by diphensyl disElenide as well as its mechanisms of action. Expand
Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds.
TLDR
Bee venom (BV) therapy (BVT), the therapeutic application of BV, has been used in traditional medicine to treat diseases, such as arthritis, rheumatism, pain, cancerous tumors, and skin diseases, and nonpeptide components which have a variety of pharmaceutical properties. Expand
D-limonene exhibits superior antihyperalgesic effects in a β-cyclodextrin-complexed form in chronic musculoskeletal pain reducing Fos protein expression on spinal cord in mice
TLDR
LIM-βCD has antihyperalgesic action superior to its uncomplexed form, with possible action in the dorsal horn of the spinal cord, suggesting the possible applicability of LIM, uncomplexing or complexed with βCD, in conditions such as FM and neuropathic pain. Expand
...
1
2
...

References

SHOWING 1-10 OF 44 REFERENCES
Antinociceptive profile of the pseudopeptide B2 bradykinin receptor antagonist NPC 18688 in mice
TLDR
The action of NPC 18688 was quite selective for the B2 receptor, and like Hoe 140, it caused graded inhibition of bradykinin (BK, 3 mol/paw)‐induced increase in mouse paw volume, with mean ID50S and MI of 6 and 9 nmol kg−1 and 56±7 and 62±6%, respectively. Expand
Extract and compounds obtained from Mandevilla velutina inhibit arachidonic acid-induced ear oedema in mice, but not rat stomach contraction.
TLDR
Results indicate that MV8608 and MV8612 exhibit both a topical and a systemic anti-inflammatory profile, presumably by a mechanism not related to inhibition of cyclooxygenase. Expand
Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action.
TLDR
It is concluded that dipyrone produces peripheral, spinal and supraspinal antinociception when assessed on formalin and capsaicin-induced pain as well as in glutamate-induced hyperalgesia in mice. Expand
Assessment of mechanisms involved in antinociception caused by sesquiterpene polygodial.
TLDR
Results show that polygodial produces pronounced systemic, spinal, and supraspinal antinociception in mice, mainly preventing the neurogenic pain produced by formalin and capsaicin, and suggest that polygamy itself or its derivatives may have potential therapeutic value for the development of new analgesic drugs. Expand
Differential effects of Mandevilla velutina compounds on paw oedema induced by phospholipase A2 and phospholipase C.
TLDR
The data show that M. velutina compounds cause potent and long-lasting inhibition of the pro-inflammatory action of phospholipase A2, an effect which may account for their reported anti-inflammatory activities. Expand
Inhibition of rat paw oedema and pleurisy by the extract fromMandevilla velutina
This study reports the oral anti-inflammatory profile of the crude extract (CE) ofMandevilla velutina, a plant which has been previously demonstrated to selectively antagonize bradykinin response ofExpand
Blockade of the bradykinin-evoked diphasic response of isolated rat duodenum by the crude extract of and compounds obtained from Mandevilla velutina.
TLDR
The influence of an aqueous/ethanolic extract of M. velutina and of two compounds purified from the plant on BK-, Ad- and K+-induced responses of the rat duodenum was analyzed in vitro. Expand
Kinin antagonist activity of compounds from Mandevilla velutina in the rat isolated uterus
TLDR
The results indicate the existence of at least two compounds in the crude extract of Mandevilla velutina that act as competitive and selective kinin antagonists on the isolated uterus of the rat. Expand
The involvement of K+ channels and Gi/o protein in the antinociceptive action of the gallic acid ethyl ester.
TLDR
GAEE produces dose-dependent and pronounced systemic, spinal and supraspinal antinociception in mice, probably via activation of K + channels and by a Gi/o pertussis toxin-sensitive mechanism. Expand
Antioedematogenic and antinociceptive actions of NPC 18521, a novel bradykinin B2 receptor antagonist.
TLDR
The novel pseudopeptide bradykinin B2 receptor antagonist, NPC 18521, has an effect with rapid onset, and produces potent and relatively long-lasting antioedematogenic and antinociceptive properties. Expand
...
1
2
3
4
5
...