Mechanisms involved in the antinociception caused by agmatine in mice.

  title={Mechanisms involved in the antinociception caused by agmatine in mice.},
  author={Adair Roberto Soares dos Santos and Vin{\'i}cius de Maria Gadotti and Gerson L Oliveira and Daiane Tibola and Ana Fl{\'a}via Paszcuk and Amaro Neto and Humberto Moreira Spindola and M{\'a}rcia Maria de Souza and Ana L{\'u}cia S Rodrigues and Jo{\~a}o Batista Calixto},
  volume={48 7},
The present study examined the antinociceptive effects of agmatine in chemical behavioural models of pain. Agmatine (1-30 mg/kg), given by i.p. route, 30 min earlier, produced dose-dependent inhibition of acetic acid-induced visceral pain, with mean ID50 value of 5.6 mg/kg. Given orally, 60 min earlier, agmatine (10-300 mg/kg) also produced dose-related inhibition of the visceral pain caused by acetic acid, with mean ID50 value of 147.3 mg/kg. Agmatine (3-100 mg/kg, i.p.) also caused… CONTINUE READING


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