Mechanisms involved in enhancement of osteoclast formation and function by low molecular weight hyaluronic acid.

@article{Ariyoshi2005MechanismsII,
  title={Mechanisms involved in enhancement of osteoclast formation and function by low molecular weight hyaluronic acid.},
  author={Wataru Ariyoshi and Tetsu Takahashi and Takahiro Kanno and Hisashi Ichimiya and Hiroshi Takano and Takeyoshi Koseki and Tatsuji Nishihara},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 19},
  pages={18967-72}
}
Hyaluronic acid (HA) is a component of the extracellular matrix that has been shown to play an important role in bone formation, resorption, and mineralization both in vivo and in vitro. We examined the effects of HA at several molecular weights on osteoclast formation and function induced by RANKL (receptor activator of NF-kappa B ligand) in a mouse monocyte cell line (RAW 264.7). HA at M(r) < 8,000 (low molecular weight HA (LMW-HA)) enhanced tartrate-resistant acid phosphatase-positive… CONTINUE READING
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Effect of Hyaluronic Acid on Osteoclastogenesis 18972 by gest on N ovem er 11

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