Mechanisms in metal genotoxicity: the significance of in vitro approaches.

@article{Lonard1988MechanismsIM,
  title={Mechanisms in metal genotoxicity: the significance of in vitro approaches.},
  author={Albert L{\'e}onard},
  journal={Mutation research},
  year={1988},
  volume={198 2},
  pages={
          321-6
        }
}
A survey of the literature published on the ability of metal salts to produce, in vitro, gene mutations, structural chromosome aberrations, sister-chromatid exchanges, to interfere with the chromosome distribution or to induce mammalian cell transformation demonstrates that the carcinogenicity of inorganic compounds is clearly associated with their genotoxicity. The induction of structural aberrations, SCEs and forward gene mutations represents the most sensitive and specific assay to assess… CONTINUE READING
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