Mechanisms in histamine-mediated secretion from adrenal chromaffin cells.

  title={Mechanisms in histamine-mediated secretion from adrenal chromaffin cells.},
  author={Philip D. Marley},
  journal={Pharmacology & therapeutics},
  volume={98 1},
The great majority of the sustained secretory response of adrenal chromaffin cells to histamine is due to extracellular Ca(2+) influx through voltage-operated Ca(2+) channels (VOCCs). This is likely to be true also for other G protein-coupled receptor (GPCR) agonists that evoke catecholamine secretion from these cells. However, the mechanism by which these GPCRs activate VOCCs is not yet clear. A substantial amount of data have established that histamine acts on H(1) receptors to activate… CONTINUE READING
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