Mechanisms for the induction of HNE- MDA- and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells.

@article{Zhou2005MechanismsFT,
  title={Mechanisms for the induction of HNE- MDA- and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells.},
  author={Jilin Zhou and Bolin Cai and Young Pyo Jang and Sophia I. Pachydaki and Ann Marie Schmidt and Janet R Sparrow},
  journal={Experimental eye research},
  year={2005},
  volume={80 4},
  pages={567-80}
}
Pathological features of age-related macular degeneration such as the formation of extracellular deposits and neovascularization are frequently viewed as outcomes of compromising processes within retinal pigment epithelial cells, but the initiating circumstances are poorly understood. Here we tested the hypothesis that photooxidation events initiated by A2E, a blue light-excitable aging fluorophore of the retinal pigment epithelium, can set the stage for altered cellular signaling and changes… CONTINUE READING
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