Mechanisms for the control of body size by a G-kinase and a downstream TGFbeta signal pathway in Caenorhabditis elegans.

@article{Nagamatsu2004MechanismsFT,
  title={Mechanisms for the control of body size by a G-kinase and a downstream TGFbeta signal pathway in Caenorhabditis elegans.},
  author={Yasuko Nagamatsu and Yasumi Ohshima},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2004},
  volume={9 1},
  pages={39-47}
}
We recently showed that egl-4 mutants in Caenorhabditis elegans have a much larger body size and that the egl-4 gene encodes cyclic GMP-dependent protein kinases (G-kinases). Cell sizes, but not cell numbers, in the major organs are increased in the mutants. Genetic interaction studies suggest that EGL-4 represses the DBL-1/TGFbeta pathway that is known to control body size. To understand the mechanisms of body size control in C. elegans, we analysed sma-2, sma-4 and sma-6 small mutants in the… CONTINUE READING

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