Mechanisms for the bone anabolic effect of parathyroid hormone treatment in humans.

  title={Mechanisms for the bone anabolic effect of parathyroid hormone treatment in humans.},
  author={Derya Aslan and Mille Dahl Andersen and Lene Bjerring Gede and Tine Kellemann de Franca and Sara Rubek J\orgensen and Peter Schwarz and Niklas R J\orgensen},
  journal={Scandinavian journal of clinical and laboratory investigation},
  volume={72 1},
Intermittent low-dose treatment with parathyroid hormone (PTH) analogues has become widely used in the treatment of severe osteoporosis. During normal physiological conditions, PTH stimulates both bone formation and resorption, and in patients with primary hyperparathyroidism, bone loss is frequent. However, development of the biochemical measurement of PTH in the 1980s led us to understand the regulation of PTH secretion and calcium metabolism which subsequently paved the way for the use of… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 69 references

parathyroid hormone increases bone formation in adult rats by activation of bone lining cells

J Davies, TJ Chambers
Endocrinology 1995;136:3632 • 1995
View 5 Excerpts
Highly Influenced

osteoprotegerin/osteoclastogenesis inhibitory factor in the stimulation of osteoclast formation by parathyroid hormone in mouse bone cells

LR McCabe, M Kockx, J Lian, J Stein, G. Stein
Eur J Endocrinol • 2000
View 7 Excerpts
Highly Influenced

TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formation

M Kanzawa, T Sugimoto, M Kanatani, K. Chihara
Endocrinology 1999;140:3552 • 1999
View 7 Excerpts
Highly Influenced

Wnt signaling: a win for bone.

Archives of biochemistry and biophysics • 2008

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