Mechanisms for the bone anabolic effect of parathyroid hormone treatment in humans.

@article{Aslan2012MechanismsFT,
  title={Mechanisms for the bone anabolic effect of parathyroid hormone treatment in humans.},
  author={Derya Aslan and Mille Dahl Andersen and Lene Bjerring Gede and Tine Kellemann de Franca and Sara Rubek J\orgensen and Peter Schwarz and Niklas R J\orgensen},
  journal={Scandinavian journal of clinical and laboratory investigation},
  year={2012},
  volume={72 1},
  pages={14-22}
}
Intermittent low-dose treatment with parathyroid hormone (PTH) analogues has become widely used in the treatment of severe osteoporosis. During normal physiological conditions, PTH stimulates both bone formation and resorption, and in patients with primary hyperparathyroidism, bone loss is frequent. However, development of the biochemical measurement of PTH in the 1980s led us to understand the regulation of PTH secretion and calcium metabolism which subsequently paved the way for the use of… CONTINUE READING

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