Mechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid Receptor

@inproceedings{Carroll2011MechanismsFT,
  title={Mechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid Receptor},
  author={Sean M. Carroll and Eric A. Ortlund and Joseph W. Thornton},
  booktitle={PLoS genetics},
  year={2011}
}
Understanding the genetic, structural, and biophysical mechanisms that caused protein functions to evolve is a central goal of molecular evolutionary studies. Ancestral sequence reconstruction (ASR) offers an experimental approach to these questions. Here we use ASR to shed light on the earliest functions and evolution of the glucocorticoid receptor (GR), a steroid-activated transcription factor that plays a key role in the regulation of vertebrate physiology. Prior work showed that GR and its… CONTINUE READING
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