Mechanisms for the Decrease of Brain Serotonin


THERE is general agreement that 5-hydroxytryptamino (5HT) is formed from 5-hydroxytryptophan (5HTP) in the presence of 5-hydroxytryptophan decarboxylase (5HTPD). It is then oxidized to 5-hydroxy indolylacetic acid (5HIAH) with monoamine oxidase (MAO). A decrease of brain 5HT has been reported in new-born animals1,2 and those made phenylketonurie by means of… (More)
DOI: 10.1038/200578a0


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