Mechanisms for selection of basic motor programs – roles for the striatum and pallidum

@article{Grillner2005MechanismsFS,
  title={Mechanisms for selection of basic motor programs – roles for the striatum and pallidum},
  author={S. Grillner and J. Hellgren and A. M{\'e}nard and K. Saitoh and M. Wikstr{\"o}m},
  journal={Trends in Neurosciences},
  year={2005},
  volume={28},
  pages={364-370}
}
The nervous system contains a toolbox of motor programs in the brainstem and spinal cord--that is, neuronal networks designed to handle the basic motor repertoire required for survival, including locomotion, posture, eye movements, breathing, chewing, swallowing and expression of emotions. The neural mechanisms responsible for selecting which motor program should be recruited at a given instant are the focus of this review. Motor programs are kept under tonic inhibition by GABAergic pallidal… Expand
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References

SHOWING 1-10 OF 73 REFERENCES
THE BASAL GANGLIA: FOCUSED SELECTION AND INHIBITION OF COMPETING MOTOR PROGRAMS
  • J. Mink
  • Biology, Medicine
  • Progress in Neurobiology
  • 1996
TLDR
The hypothesis states that the basal ganglia do not generate movements, and when voluntary movement is generated by cerebral cortical and cerebellar mechanisms, the basal Ganglia act broadly to inhibit competing motor mechanisms that would otherwise interfere with the desired movement. Expand
Role of basal ganglia–brainstem pathways in the control of motor behaviors
TLDR
It can be proposed that dysfunction of the basal ganglia-brainstem system together with that of cortico-basal ganglia loop underlies the pathogenesis of behavioral disturbances expressed in basal Ganglia dysfunction. Expand
Role of the basal ganglia in the control of purposive saccadic eye movements.
TLDR
The interaction between cortical and dopaminergic inputs to CD neurons may underlie the behavioral adaptation toward purposeful saccades, which reflects working memory, expectation, and attention. Expand
Cortical and brainstem control of locomotion.
TLDR
It is suggested that, during both locomotion and reaching movements, the final expression of descending signals is influenced by the state and excitability of the spinal circuits upon which they impinge. Expand
Inhibitory control of neostriatal projection neurons by GABAergic interneurons
TLDR
Paired whole-cell recordings are used to show that inhibitory synaptic potentials generated from single interneurons are sufficiently powerful to delay or entirely block the generation of action potentials in a large number of projection neurons simultaneously. Expand
Neurobiological bases of rhythmic motor acts in vertebrates.
TLDR
The hypothesis that different parts of the network controlling locomotion can be used in a variety of other motor acts, including learned ones, is reviewed. Expand
Role of basal ganglia-brainstem systems in the control of postural muscle tone and locomotion.
TLDR
It is proposed that dysfunction of the basal ganglia-brainstem system, together with that of the cortico-basal ganglia loop, underlies the pathogenesis of motor disturbances expressed in basal Ganglia diseases. Expand
Synaptic organisation of the basal ganglia
TLDR
It is concluded that the essential concept of the direct and indirect pathways of information flow through the basal ganglia remains intact but that the role of the indirect pathway is more complex than previously suggested and that neurons of the globus pallidus are in a position to control the activity of virtually the whole of the basalganglia. Expand
Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction
TLDR
It is concluded that disorders of the basal ganglia may include dysfunction of the nigrotegmental (basal ganglia-brainstem) systems, which consequently leads to the production of abnormal muscle tone and gait disturbance. Expand
Innate versus learned movements--a false dichotomy?
It is argued that the nervous systems of vertebrates are equipped with a "motor infrastructure," which enables them to perform the full extent of the motor repertoire characteristic of their… Expand
...
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