Mechanisms for lymphocytic choriomeningitis virus glycoprotein cleavage, transport, and incorporation into virions.

@article{Kunz2003MechanismsFL,
  title={Mechanisms for lymphocytic choriomeningitis virus glycoprotein cleavage, transport, and incorporation into virions.},
  author={Stefan Kunz and Kurt H. Edelmann and Juan-Carlos de la Torre and Robert Gorney and Michael B A Oldstone},
  journal={Virology},
  year={2003},
  volume={314 1},
  pages={168-78}
}
The glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV) serves as virus attachment protein to its receptor on host cells and is a key determinant for cell tropism, pathogenesis, and epidemiology of the virus. The GP of LCMV is posttranslationally cleaved by the subtilase SKI-1/S1P into two subunits, the peripheral GP1, which is implicated in receptor binding, and the transmembrane GP2 that is structurally similar to the fusion active membrane proximal portions of the glycoproteins of… CONTINUE READING

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