Mechanisms for induction of mutations and chromosome alterations.

  title={Mechanisms for induction of mutations and chromosome alterations.},
  author={Adayapalam Tyagarajan Natarajan},
  journal={Environmental Health Perspectives},
  pages={225 - 229}
Genotoxic agents induce chromosomal alterations, such as aberrations, micronuclei, and sister chromatid exchanges as well as mutations both in vivo and in vitro. Ionizing radiation and typical radiomimmetic agents such as bleomycin are very efficient inducers of chromosomal aberrations. The type of aberrations induced by these agents are cell-cycle dependent, i.e., chromosome type in pre-replication stages and chromatid type in post-replication stages of the cell cycle. Under optimal DNA repair… CONTINUE READING


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