Mechanisms for hypoxia detection in O2-sensitive cells.

  title={Mechanisms for hypoxia detection in O2-sensitive cells.},
  author={Naoji Fujishiro and Yutaka Endo and Akira Warashina and Masumi Inoue},
  journal={The Japanese journal of physiology},
  volume={54 2},
Since O(2) is the bare necessity for multicellular organisms, they develop multiple protective mechanisms against hypoxia. Mammals will adapt to hypoxia in short and long terms. The short-term responses include enhancement of the respiratory and cardiac functions, adrenaline secretion from adrenal medullary cells, and pulmonary vasoconstriction, whereas the long-term response is the increase in erythropoietin production with the consequent increase in red blood cells. Although much work has… CONTINUE READING