Mechanisms for evolving hypervariability: the case of conopeptides.

@article{Conticello2001MechanismsFE,
  title={Mechanisms for evolving hypervariability: the case of conopeptides.},
  author={Silvestro G. Conticello and Yoav Gilad and Nili Avidan and Edna Ben-Asher and Zehava Levy and Mike Fainzilber},
  journal={Molecular biology and evolution},
  year={2001},
  volume={18 2},
  pages={120-31}
}
Hypervariability is a prominent feature of large gene families that mediate interactions between organisms, such as venom-derived toxins or immunoglobulins. In order to study mechanisms for evolution of hypervariability, we examined an EST-generated assemblage of 170 distinct conopeptide sequences from the venoms of five species of marine Conus snails. These sequences were assigned to eight gene families, defined by conserved elements in the signal domain and untranslated regions. Order-of… CONTINUE READING
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