Mechanisms for T cell receptor triggering

@article{Merwe2011MechanismsFT,
  title={Mechanisms for T cell receptor triggering},
  author={P. Merwe and Omer Dushek},
  journal={Nature Reviews Immunology},
  year={2011},
  volume={11},
  pages={47-55}
}
There is considerable controversy about the mechanism of T cell receptor (TCR) triggering, the process by which the TCR tranduces signals across the plasma membrane after binding to its ligand (an agonist peptide complexed with an MHC molecule). Three main types of mechanism have been proposed, which involve aggregation, conformational change and segregation. Here, we review recently published evidence for each type of mechanism and conclude that all three may be involved. This complexity may… Expand
347 Citations
Elementary Steps in T Cell Receptor Triggering
  • 8
TCR Signaling: Mechanisms of Initiation and Propagation.
  • 136
The T-Cell Receptor Signalosome
Structural understanding of T cell receptor triggering
  • 7
  • PDF
Molecular mechanisms of T cell sensitivity to antigen
  • 21
Initiation of TCR Phosphorylation and Signal Transduction
  • 39
Lipid in T-cell receptor transmembrane signaling.
  • 16
Dual Role of CD4 in Peripheral T Lymphocytes
  • 14
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 120 REFERENCES
Molecular mechanisms involved in T cell receptor triggering.
  • 81
Initiation of TCR signalling revisited.
  • 32
Affinity threshold for thymic selection through a T-cell receptor–co-receptor zipper
  • 135
Direct observation of ligand recognition by T cells
  • 741
  • PDF
A role for "self" in T-cell activation.
  • 53
The molecular basis of TCR germline bias for MHC is surprisingly simple
  • 200
  • PDF
...
1
2
3
4
5
...