Mechanisms for T cell receptor triggering

@article{Merwe2011MechanismsFT,
  title={Mechanisms for T cell receptor triggering},
  author={P. Anton van der Merwe and Omer Dushek},
  journal={Nature Reviews Immunology},
  year={2011},
  volume={11},
  pages={47-55}
}
There is considerable controversy about the mechanism of T cell receptor (TCR) triggering, the process by which the TCR tranduces signals across the plasma membrane after binding to its ligand (an agonist peptide complexed with an MHC molecule). Three main types of mechanism have been proposed, which involve aggregation, conformational change and segregation. Here, we review recently published evidence for each type of mechanism and conclude that all three may be involved. This complexity may… 

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