Mechanisms for Intracellular Calcium Regulation in Heart: I. Stopped-Flow Measurements of Ca++ Uptake by Cardiac Mitochondria

@inproceedings{Scarpa1973MechanismsFI,
  title={Mechanisms for Intracellular Calcium Regulation in Heart: I. Stopped-Flow Measurements of Ca++ Uptake by Cardiac Mitochondria},
  author={Antonio Scarpa and Pierpaolo Graziotti},
  year={1973}
}
Initial velocities of energy-dependent Ca++ uptake were measured by stopped-flow and dual-wavelength techniques in mitochondria isolated from hearts of rats, guinea pigs, squirrels, pigeons, and frogs. The rate of Ca++ uptake by rat heart mitochondria was 0.05 nmol/mg/s at 5 µM Ca++ and increased sigmoidally to 8 nmol/mg/s at 200 µM Ca++. A Hill plot of the data yields a straight line with slope n of 2, indicating a cooperativity for Ca++ transport in cardiac mitochondria. Comparable rates of… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 59 REFERENCES

Calcium and Striated Muscle

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Heart: excitation-contraction coupling

G. A. LANOER
  • Annu. Rev. Physiol
  • 1973
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Active transport of calcium ion in sarcoplasmic membranes.

  • Annual review of biophysics and bioengineering
  • 1972
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Contractile proteins of the heart

A. M. KATz
  • Physiol. Rev
  • 1970
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Mitochondria and calcium ion transport.

  • The Biochemical journal
  • 1970
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Control of muscle contraction.

  • Quarterly reviews of biophysics
  • 1969
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL