Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C–Cdc20 complex

  title={Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C–Cdc20 complex},
  author={G. Sedgwick and D. Hayward and B. Di Fiore and M. Pardo and L. Yu and J. Pines and J. Nilsson},
  journal={The EMBO Journal},
  • G. Sedgwick, D. Hayward, +4 authors J. Nilsson
  • Published 2013
  • Biology, Medicine
  • The EMBO Journal
  • The Anaphase Promoting Complex/Cyclosome (APC/C) in complex with its co‐activator Cdc20 is responsible for targeting proteins for ubiquitin‐mediated degradation during mitosis. The activity of APC/C–Cdc20 is inhibited during prometaphase by the Spindle Assembly Checkpoint (SAC) yet certain substrates escape this inhibition. Nek2A degradation during prometaphase depends on direct binding of Nek2A to the APC/C via a C‐terminal MR dipeptide but whether this motif alone is sufficient is not clear… CONTINUE READING
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