Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex.

@article{Sedgwick2013MechanismsCT,
  title={Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex.},
  author={Garry Gray Sedgwick and Daniel Geoffrey Hayward and Barbara Di Fiore and M. L. Morena Pardo and Lu Yu and Jonathon Noe Pines and Jakob Nilsson},
  journal={The EMBO journal},
  year={2013},
  volume={32 2},
  pages={
          303-14
        }
}
The Anaphase Promoting Complex/Cyclosome (APC/C) in complex with its co-activator Cdc20 is responsible for targeting proteins for ubiquitin-mediated degradation during mitosis. The activity of APC/C-Cdc20 is inhibited during prometaphase by the Spindle Assembly Checkpoint (SAC) yet certain substrates escape this inhibition. Nek2A degradation during prometaphase depends on direct binding of Nek2A to the APC/C via a C-terminal MR dipeptide but whether this motif alone is sufficient is not clear… CONTINUE READING
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