Mechanisms controlling gene expression by nuclear calcium signals.

  title={Mechanisms controlling gene expression by nuclear calcium signals.},
  author={Giles E Hardingham and Francisco H. Cruzalegui and Sangeeta Chawla and Hilmar Bading},
  journal={Cell calcium},
  volume={23 2-3},
Nuclear calcium is an important regulator of gene expression following membrane depolarisation of electrically excitable cells. Here we describe nuclear calcium transients in hippocampal neurons following activation of calcium influx through L-type voltage-sensitive calcium channels and N-methyl-D-aspartate (NMDA) receptors, as well as following calcium release from intracellular caffeine-sensitive stores. Increases in nuclear calcium activate gene transcription by a mechanism that is distinct… CONTINUE READING

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