Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells.

Abstract

Extensive studies have implicated the role of dietary fatty acids in prostatecancer progression. Platelet-type 12-Lipoxygenase (12-LOX) has beenshown to regulate growth, metastasis, and angiogenesis of prostate cancer. The effect of two 12-LOX inhibitors, Baicalein and N-benzyl-N-hydroxy-5-phenylpentamide (BHPP), on the mechanisms controlling cell cycle… (More)

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@article{Pidgeon2002MechanismsCC, title={Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells.}, author={Graham P. Pidgeon and Mustapha Kandouz and Anthony Meram and Kenneth V. Honn}, journal={Cancer research}, year={2002}, volume={62 9}, pages={2721-7} }